Patients with BAP1-mutated renal cell carcinoma who were treated with Lynparza obtained responses with favorable side effect profiles. Patients with renal cell carcinoma (RCC) whose tumors had gene ...

The endoplasmic reticulum (ER) is classically linked to metabolic homeostasis via the activation of unfolded protein response (UPR), which is instructed by multiple transcriptional regulatory cascades ...

A new study reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). The ...

New study from researchers in Finland and the United Kingdom reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ...

Comparative analysis of the chromosomal origins of circulating nucleic acids in breast and prostate cancer. Background: CDKN2A and NF2 are inactivated in most MPM, but no other recurrent mutations are ...

The BAP1 gene is mutated in up to 20% of liver cancer patients, but just how the abnormality promotes the growth of liver tumors is a big unknown. Researchers at Hubrecht Institute and Radboud ...

Researchers have identified covalently closed circular RNAs (circRNAs) from key genes involved in leukemia development and provided greater understanding of their roles in haematological malignancies.

Perioperative chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone in gallbladder carcinoma or in front of radical resection ...

Immunotherapies using immune checkpoint inhibitors (ICI) have dramatically improved cancer survival in the last decade, resulting in the Nobel Prize for Medicine in 2018. Unfortunately, a significant ...