A researcher with the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases at UT Health San Antonio has ...

Microglia are primary immune cells that safeguard the mammalian brain, partly by devouring or 'phagocytosing' pathogens and toxic debris. Recent genetic studies have consistently highlighted the role ...

New research suggests that compulsive behavior may be less about willpower failure and more about inflammation quietly disrupting the brain’s reward and habit circuits. While the idea of “hidden brain ...

Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states. But the molecular mechanisms that ...

Researchers analyzed thousands of microglia from different brain regions of deceased patients who had been diagnosed with a variety of neuropsychiatric and neurodegenerative disorders. Their results ...

By Dr. Priyom Bose, Ph.D. A new study uncovers interferon gamma as both a powerful blood-based signal of Alzheimer’s disease ( AD ) and a potential mechanistic bridge between genetic risk and damaging ...

Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 ...

In diseases driven by dysfunctional microglia, could replacing them with healthy versions prevent, or even reverse, pathology? Yes, suggest two papers in the June 18 Neuron. Both describe how mice ...

Researchers at University of Tsukuba have discovered that an immunosuppressive drug affects microglia, the resident immune cells of the brain. In mouse models, the drug reduced levels of guanosine ...

The Laboratory of Neuroimmunology of the Institute of Experimental Medicine, Budapest (IEM), Hungary, led by Ádám Dénes, describes the presence of a direct interaction site between microglial cells ...