Proteins are large, complex molecules that carry out the tasks of life. They direct our bodies' activities, organize our thoughts, and defend us against infection, keeping us healthy. But in their ...

Structural mass spectrometry has emerged as a powerful approach to elucidate the three‐dimensional conformations of proteins and their complexes under near‐physiological conditions. In particular, ...

Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding where ...

Historically, these factors have made the identification of proteins incredibly challenging. The advent of mass spectrometry (MS) and MS-based proteomics helped to change that. 2 MS is an analytical ...

Antibody arrays: removal of high abundance proteins is not required, but antibody availability limits protein detection. Mass spectrometry: “hypothesis-free” protein detection is affected by high ...

Technological advances in mass spectrometry are aiding researchers to image and characterize protein and other cellular components with increasing resolution. Using native ambient mass spectrometry ...

This episode of the Pharmaron DMPK Insights Podcast Series features Scott Summerfield (Executive Director of Metabolism at Pharmaron) and John Mehl (consultant and previous director at GSK, and ...

Enhancing protein identification accuracy is vital for proteomics; this article explores key technologies and statistical methods involved.

A screening technique commonly used in drug discovery can yield important details about the actions of molecular ‘glues’ in protein interactions. Molecular glues are emerging as powerful therapeutic ...

This overview explains how proteomics sample preparation underpins mass spectrometry performance. It details best practices ...

In a new study, published in Cell, researchers describe a newfound mechanism for creating proteins in a giant DNA virus, comparable to a mechanism in eukaryotic cells. The finding challenges the dogma ...