Europe PMC

Neurophysiological correlates of affiliative behaviour between humans and dogs.

Few physiological parameters for positive human-companion animal contact have been identified and those that are established have all been in humans. The implication is that if the physiological ...
Europe PMC

SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability

COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety and cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild ...
Europe PMC

Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors.

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Europe PMC

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.

In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD +) biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide (NMN) availability is a ...
Europe PMC

Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.

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Europe PMC

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.
Europe PMC

BNT162b2 Vaccine: possible codons misreading, errors in protein synthesis and alternative splicing's anomalies

BNT162b2 vaccine against Covid-19 is composed of an RNA having 4284 nucleotides , divided into 6 sections , which bring the information to create a factory of S Spike proteins , the ones used by ...
Europe PMC

Can chatbots ever provide more social connection than humans?

Around the world, hundreds of millions of people have used social chatbots designed to provide companionship to their users. But can people reap genuine social benefits from interacting with chatbots?
Europe PMC

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

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Europe PMC

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes.

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes.
Europe PMC

Regional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase.

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